Advanced Neuropsychotropic, Anxiolytic & BDNF-Modulating Heptapeptide

Investigate the intersection of immunology, neurochemistry, and behavioral science with Selank (10 MG), an elite-tier synthetic heptapeptide engineered for advanced laboratory research into anxiety modulation, cognitive enhancement, and neuroprotection. Originally developed by the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank is structurally derived from the endogenous immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg) and strategically elongated at the C-terminus with a three-amino-acid Pro-Gly-Pro motif. This molecular modification dramatically enhances metabolic stability and protects the core peptide pharmacophore against rapid enzymatic degradation.

Unlike classical benzodiazepines that induce sedation, cognitive impairment, and dependency, Selank operates through subtle allosteric modulation of the GABAergic system and the targeted inhibition of enkephalin-degrading enzymes (enkephalinases). This mechanism prolongs the biological half-life of endogenous circulating enkephalins while simultaneously upregulating the synthesis of brain-derived neurotrophic factor (BDNF) within the hippocampus and basal forebrain. It provides researchers with an exceptional biological model for studying stress mitigation, memory formation, and neuro-immune cross-talk without the confounding variables of CNS depression or withdrawal liability.

Key Product Highlights

• Enkephalinase Inhibition: Competitively blocks enkephalin-degrading enzymes, significantly extending the systemic and localized half-life of natural endogenous enkephalins to study natural stress relief and mood regulation.

• GABAergic Allosteric Modulation: Modulates GABA-A receptor activity without altering receptor binding affinity, providing an ideal model for investigating anxiolytic pathways without sedation or motor impairment.

• BDNF Upregulation: Stimulates the expression and synthesis of brain-derived neurotrophic factor (BDNF) in the basal forebrain and hippocampus, facilitating research into neuroplasticity, memory formation, and cognitive repair.

• Neuro-Immune Bridge: Retains the core immunomodulatory characteristics of its parent peptide, tuftsin, making it a valuable tool for studying the relationship between systemic immune responses and central nervous system function.

• Non-Sedative & Non-Addictive Profile: Delivers pronounced neuropsychotropic and anti-stress effects without triggering amnesia, withdrawal syndromes, or tolerance buildup.

• Ultra-Pure Specification: Lyophilized and synthesized at an elite $\ge 99\%$ purity level (HPLC and Mass Spectrometry verified) to ensure absolute precision and flawless reproducibility in complex cellular and behavioral assays.