Targeted Tripeptide for Intracellular Anti-Inflammatory & Mucosal Research

Advance your investigations into cellular inflammation, immune modulation, and mucosal barrier repair with KPV (10 MG), a highly pure, naturally derived tripeptide corresponding to the C-terminal catalytic fragment (residues 11–13) of alpha-melanocyte-stimulating hormone ($\alpha$-MSH). Despite its ultra-compact size, KPV retains the potent anti-inflammatory properties of its parent hormone without exerting unwanted melanogenic pigmentation or steroid-like endocrine side effects.

Because of its minimal molecular weight and high affinity for the PepT1 peptide transporter, KPV readily crosses cellular and epithelial membranes to operate directly within the cytoplasm and nucleus. This makes it an indispensable research compound for laboratory models studying inflammatory bowel disease (IBD), intestinal mucosal barrier integrity, dermatological redness and irritation, and oxidative stress-induced tissue damage.

Key Product Highlights

• Direct Intracellular Action: Utilizes the PepT1 di/tripeptide transporter to cross cell membranes, entering the nucleus to directly modulate inflammatory signaling cascades rather than relying solely on surface receptor binding.

• NF-$\kappa$B Pathway Inhibition: Competitively blocks the nuclear translocation of NF-$\kappa$B (p65RelA) and stabilizes I$\kappa$B$\alpha$, effectively halting the downstream transcription of major pro-inflammatory cytokines including TNF-$\alpha$, IL-1$\beta$, and IL-6.

• Gastrointestinal & Mucosal Protection: Exceptionally valued in research models of ulcerative colitis and intestinal inflammation for its ability to support epithelial barrier integrity, accelerate mucosal healing, and reduce colonic myeloperoxidase (MPO) activity.

• Dermatological & Tissue Repair: Ideal for investigating epithelial recovery, reducing oxidative stress, suppressing neutrophil extracellular trap (NETosis) formation, and resolving localized tissue irritation in cosmetic and wound-healing models.

• Non-Hormonal & Non-Melanogenic: Delivers the targeted anti-inflammatory and cytoprotective benefits of $\alpha$-MSH without triggering pigmentation changes or endocrine disruptions.

• Ultra-Pure Specification: Lyophilized and manufactured at $\ge 98\%$ purity (HPLC verified) to ensure consistent pharmacokinetic profiles and uncompromised experimental reliability in complex biological assays.