Advanced Mitochondria-Targeted Peptide for Cardiolipin Stabilization & Bioenergetic Restoration

Investigate the forefront of mitochondrial physiology, cellular bioenergetics, and age-related metabolic research with SS-31 (Elamipretide) 50 MG, an elite-tier synthetic tetrapeptide engineered to selectively target and restore the inner mitochondrial membrane (IMM). Structurally classified among the Szeto-Schiller (SS) class of cell-permeable peptides, SS-31 features an alternating cationic-aromatic amino acid motif (D-Arg-Dmt-Lys-Phe-NH2) incorporating the modified amino acid 2′,6′-dimethyltyrosine (Dmt). This unique structural architecture allows the peptide to effortlessly penetrate cellular membranes and accumulate specifically within the mitochondrial matrix, independent of mitochondrial membrane potential.

Unlike conventional exogenous antioxidants that indiscriminately scavenge free radicals and can disrupt vital cellular signaling pathways, SS-31 operates upstream at the primary source of oxidative stress. It selectively binds with high affinity to cardiolipin—a critical anionic phospholipid expressed exclusively on the inner mitochondrial membrane. By stabilizing cardiolipin and protecting its association with cytochrome c, SS-31 prevents the conversion of cytochrome c into a pathological peroxidase enzyme while preserving its essential role as an electron carrier. This mechanism optimizes electron transport chain (ETC) supercomplex assembly, restores mitochondrial cristae architecture, enhances ATP synthesis, and significantly attenuates reactive oxygen species (ROS) production in ischemic, aging, and stressed cellular models.

Key Product Highlights

• Cardiolipin Stabilization: Binds selectively with high affinity to mitochondrial cardiolipin via electrostatic and hydrophobic interactions, preventing lipid peroxidation and protecting the structural integrity of the inner mitochondrial membrane.

• Cytochrome c Protection: Modulates the cytochrome c/cardiolipin complex by inhibiting pathological peroxidase activity while preserving cytochrome c‘s vital function as an electron carrier within the respiratory chain.

• Bioenergetic & ATP Optimization: Promotes the efficient assembly of respiratory complexes into supercomplexes, enhancing electron transport kinetics, state 3 respiration, and overall mitochondrial ATP production.

• Upstream ROS Mitigation: Attenuates mitochondrial reactive oxygen species (ROS) production at the source without acting as an indiscriminate systemic antioxidant, preserving normal cellular physiological signaling.

• Cristae Architecture Preservation: Demonstrated in extensive laboratory models to preserve mitochondrial cristae morphology, prevent mitochondrial swelling, and rescue cellular energy homeostasis following ischemia-reperfusion injury and aging.

• Ultra-Pure Specification: Lyophilized and synthesized at an elite ≥98% purity level (HPLC and Mass Spectrometry verified) to guarantee exceptional precision, stability, and reproducibility in demanding metabolic and cellular assays.